Fundraising for DNKO Projects
The Canine Glioma trial will be the first project we are raising money to cover. Upon a successful canine trial, it will be followed by a Phase I trial in humans testing the LITT + LTSL-Dox for safety.
In addition we plan to raise funds dedicated to overhead, and operations for DNKO, and also to enable additional scientific discovery, research and outreach collaborations".
While we know there are large amounts of funds required, (see below) any amount helps. We're in the process of setting up donation channels, please contact kate@DNKO.net in the interim.
LITT & LTSL-Dox
Canine Glioma Trial
Companion dogs have brain tumors too, and so prior to a Phase I in humans, we are currently planning a small clinical trial in canine patients with Glioma to test LITT + LTSL-Dox. The trial will be a new collaboration between the Piedmont Brain Tumor Center in Atlanta, the Preston Robert Tisch Brain Tumor Center at Duke University, and NC State Veterinary College, where they are already conducting Laser Interstitial Thermal Therapy (LITT) for Canine Glioma. We are planning the trial in 6 canine patients which is estimated to cost $20,000 per patient, and so a total of $120,000.
Sponsoring one dog in a trial would therefore be $20,000.
Any amount helps.
Phase I HumanTrials
If the canine study LITT + LTSL-Dox shows safety and even efficacy, then we will want to move swiftly to a Phase I safety trial in 12 human patients with recurrent Glioblastoma, at an initial estimated cost of ~$1.2M. There may also be an opportunity to apply for approval and carry out compassionate use.
Cost here are estimated to be ~$100,000 per patient, and, again, could represent a dedicated donation for one patient to participate and perhaps get the benefits of this new combination technology.
And again, any donation helps.